IMMUNOLOGY2025™

May 3–7, 2025 | Honolulu, Hawai’i, USA

Major Symposia

Sunday, May 4 | 7:00 AM – 10:30 AM | Ballroom B

Major Symposium A
FoxP3+ Expressing Regulatory T Cells: Twenty-plus Years After

Chairs:

  • Alexander Rudensky, HHMI, Mem. Sloan Kettering Cancer Ctr., Sloan Kettering Inst., USA
  • Shimon Sakaguchi, iFReC, WPI, Osaka Univ., JPN

Speakers:

  • Megan K. Levings, Univ. of British Columbia, CAN, Tolerance induction with engineered Tregs
  • Dan Littman, HHMI, NYU Grossman Sch. of Med., USA, Antigen presentation in the programming of intestinal T cells
  • Alexander Rudensky, HHMI, Mem. Sloan Kettering Cancer Ctr., Sloan Kettering Inst., USA, Genetic mechanisms of regulatory T cell differentiation and function
  • Shimon Sakaguchi, iFRec, WPI, Osaka Univ., JPN
  • Lucy Walker, Univ. Col. London, GBR, CTLA-4 mediated control of autoimmunity

Sunday, May 4 | 7:00 AM – 10:30 AM | Ballroom C

Major Symposium B
Systems Immunology and AI: Transforming Data into Predictive Immunological Insights

Chairs:

  • Catherine Blish, Stanford Univ., USA
  • John Tsang, Yale Univ., USA

Speakers:

  • Grégoire Altan-Bonnet, NCI, NIH, USA, Navigating the high-dimensional space of cancer immunotherapies
  • Catherine Blish, Stanford Univ., USA, Mapping cell-cell communication networks to understand host-pathogen interactions
  • Sophia Liu, Ragon Inst. of MGH, MIT, and Harvard, USA, Evolution of adaptive immunity in tissues over time
  • John Tsang, Yale Univ., USA
  • Alexandra-Chloe Villani, Massachusetts Gen. Hosp.; Harvard Med. Sch., Broad Inst. of MIT & Harvard, USA, Learning the rules of human immune tolerance through the lenses of single-cell genomics

Monday, May 5 | 7:00 AM – 10:30 AM | Ballroom B

Major Symposium C
Emerging Discoveries at Brain-Immune Interfaces

Chairs:

  • Dorian McGavern, NINDS, NIH, USA
  • Anna Victoria Molofsky, UCSF, USA

Speakers:

  • Gloria Choi, MIT, USA, Neuroimmune interactions shaping social behavior
  • Gou Young Koh, Inst. for Basic Sci., KOR, Exploring meningeal lymphatics and their connections for brain clearance and immunosurveillance
  • Dorian McGavern, NINDS, NIH, USA, Immunological defense of dynamic vascular barriers in the meninges
  • Anna Victoria Molofsky, UCSF, USA, Cytokine regulation of brain development
  • Christoph Thaiss, Arc Inst.; Stanford University, USA, Environment-body-brain interactions

Monday, May 5 | 7:00 AM – 10:30 AM | Ballroom C

Major Symposium D

Chairs:

Memory and Effector B Cells in Health and Disease
  • F. Eun-Hung Lee, Emory Univ. Sch. of Med., USA
  • Eric Meffre, Stanford Univ., USA

Speakers:

  • F. Eun-Hung Lee, Emory Univ. Sch. of Med., USA, Understanding the complexity of human plasma cells
  • Eric Meffre, Stanford Univ., USA
  • Michel Nussenzweig, HHMI, Rockefeller Univ., USA
  • Jean-Claude Weill, Inst. Necker-Enfants Malades, FRA, Human memory B cells: the mystery of their longevity
  • Julie Zikherman, UCSF, USA, Balancing tolerance and immunity at the BCR

Tuesday, May 6 | 7:00 AM – 10:30 AM | Ballroom B

Major Symposium E
Evolving Immunologic Concepts Linking Infection and Autoimmunity

Chairs:

  • Judith James, Oklahoma Med. Res. Fndn., USA
  • Wei Jiang, Med. Univ. of South Carolina, USA

Speakers:

  • Hisashi Arase, iFReC, Osaka Univ., JPN, Self and neoself discrimination by T cells in the pathogenesis of autoimmune diseases
  • Judith James, Oklahoma Med. Res. Fndn., USA
  • Wei Jiang, Med. Univ. of South Carolina, USA, Staphylococcus aureus peptidoglycan (PGN) induces pathogenic autoantibody production via autoreactive B cell receptor clonal selection, implications in systemic lupus erythematosus
  • Martin Kriegel, Univ. of Münster, DEU, Gut commensal translocation in extraintestinal autoimmunity
  • James J. Moon, Massachusetts Gen. Hosp.; Harvard Med. Sch., USA, T cell epitope spreading from microbial to autoantigens

Tuesday, May 6 | 7:00 AM – 10:30 AM | Ballroom C

Major Symposium F
Innate Immunity: Initiation and Regulation

Chairs:

  • Greg Barton, HHMI, Univ. of California, Berkeley, USA
  • Dan Stetson, Univ. of Washington, USA

Speakers:

  • Diana C. Hargreaves, Salk Inst. for Bio. Sts., USA, BAF complexes and tumor immunity
  • Lingyin Li, Arc Inst.; Stanford Univ., USA, The immunotransmitter cGAMP in cancer and autoimmunity
  • Pingwei Li, Texas A&M Univ., USA, The molecular basis of DNA sensing through the cGAS-STING pathway
  • Kensuke Miyake, Chiba Univ., JPN, Toll-like receptor responses to lysosomal nucleic acid stress
  • Dan Stetson, Univ. of Washington, USA

Wednesday, May 7 | 7:00 AM – 10:30 AM | Ballroom B

Major Symposium G
Lymphatic Immunophysiology

Chairs:

  • Gwendalyn J. Randolph, Washington Univ. Sch. of Med., St. Louis, USA
  • Melody Swartz, Univ. of Chicago, USA

Speakers:

  • Sandro Da Mesquita, Mayo Clin., Florida, USA, Modulation of brain physiology and pathology by the meningeal lymphatic system
  • Gwendalyn J. Randolph, Washington Univ. Sch. of Med., St. Louis, USA, Intestinal lymphatics and lymphoid tissue in gut immunophysiology
  • Susan R. Schwab, New York Univ. Grossman Sch. of Med., USA, Far from home: T cell migration through non-lymphoid tissues
  • Melody Swartz, Univ. of Chicago, USA, Lymphatic clotting and its effects on adaptive immune responses

Wednesday, May 7 | 7:00 AM – 10:30 AM | Ballroom C

Major Symposium H
T Cell Differentiation in Cancer

Chairs:

  • Ana C. Anderson, Gene Lay Inst. of Immunol. and Inflammation, Brigham & Women’s Hosp., Harvard Med. Sch., USA
  • Mary Philip, Vanderbilt Univ. Sch. of Med., USA

Speakers:

  • Niroshana Anandasabapathy, Weill Cornell Med., USA, PD-1 and T cell specification
  • Ana C. Anderson, Gene Lay Inst. of Immunol. and Inflammation, Brigham & Women’s Hosp.; Harvard Med. Sch., USA
  • Mary Philip, Vanderbilt Univ. Sch. of Med., USA, Early CD8+ T cell fate commitment in cancer and infection
  • Stefani Spranger, Koch Inst. for Integrative Cancer Res., MIT, USA, Not all T cell responses are equal: The role of dendritic cells in shaping anti-tumor immunity
  • Ben Youngblood, St. Jude Children’s Res. Med. Hosp., USA, Reverse translation of patient-identified epigenetic regulators limiting durable tumor immunotherapy