IMMUNOLOGY2025™

May 3–7, 2025 | Honolulu, Hawai’i, USA

Major Symposia

Sunday, May 4 | 7:00 – 10:30 | Ballroom B

Major Symposium A
FoxP3+ Expressing Regulatory T Cells: Twenty-plus Years After

Chairs:

  • Alexander Rudensky, HHMI, Mem. Sloan Kettering Cancer Ctr., Sloan Kettering Inst., USA
  • Shimon Sakaguchi, iFReC, WPI, Osaka Univ., JPN

Speakers:

  • Alexander Rudensky, HHMI, Mem. Sloan Kettering Cancer Ctr., Sloan Kettering Inst., USA, Genetic mechanisms of regulatory T cell differentiation and function
  • Wei Hu, Yale Univ. Sch. of Med., USA, Transcriptional basis for Treg mediated control of autoimmunity
  • Min-Jhen Jheng, Mayo Clin. Arizona, USA, Lung-resident CCR8+ ST2+ regulatory T cells effectively alleviate chronic type 2 airway inflammation and asthma phenotype in mice
  • Lucy Walker, Univ. Col. London, GBR, CTLA-4 mediated control of autoimmunity
  • Jianliang Zhang, Emory Univ. Sch. of Med., USA, T-bet+ CXCR3+ VAT Tregs limit antiviral response in adipose tissue and suppress virally-induced insulin resistance
  • Megan K. Levings, Univ. of British Columbia, CAN, Tolerance induction with engineered Tregs
  • Shimon Sakaguchi, iFRec, WPI, Osaka Univ., JPN, Induction of regulatory T cells for immune tolerance

Sunday, May 4 | 7:00 – 10:30 | Ballroom C

Major Symposium B
Systems Immunology and AI: Transforming Data into Predictive Immunological Insights

Chairs:

  • Catherine Blish, Stanford Univ., USA
  • John Tsang, Yale Univ., USA

Speakers:

  • Grégoire Altan-Bonnet, NCI, NIH, USA, Navigating the high-dimensional space of cancer immunotherapies
  • Catherine Blish, Stanford Univ., USA, Mapping cell-cell communication networks to understand host-pathogen interactions
  • Seongryong Kim, Korea Advanced Inst. of Sci. and Technol., Korea, Cross-tissue integration of human cell identifies common cellular phenotypes across human diseases
  • Sophia Liu, Ragon Inst. of MGH, MIT, and Harvard, USA, Evolution of adaptive immunity in tissues over time
  • Haripriya Vaidehi Narayanan, UCLA, USA, Topological measures on phylogenetic trees of the antibody repertoire reveal the underlying kinetics of B cell fate decisions
  • John Tsang, Yale Univ., USA, Using systems immunology to characterize vaccine response
  • Alexandra-Chloe Villani, Massachusetts Gen. Hosp.; Harvard Med. Sch., Broad Inst. of MIT & Harvard, USA, Learning the rules of human immune tolerance through the lenses of single-cell genomics

Monday, May 5 | 7:00 – 10:30 | Ballroom B

Major Symposium C
Emerging Discoveries at Brain-Immune Interfaces

Chairs:

  • Dorian McGavern, NINDS, NIH, USA
  • Anna Victoria Molofsky, UCSF, USA

Speakers:

  • Gloria Choi, MIT, USA, Neuroimmune interactions shaping social behavior
  • Anna Victoria Molofsky, UCSF, USA, Cytokine regulation of brain development
  • Stacie L. Lin, Harvard Med. Sch., Autoantibody deposition in the neurovasculature promotes interferon-𝛼 release to drive neuropsychiatric lupus
  • Daniel Mucida, HHMI, Rockefeller Univ., USA, Neuro-immune interactions in the gut
  • Lingyang Kong, Univ. of Pennsylvania, USA, Clonally expanded CD8+ T cells recognize cryptic epitopes induced by TDP-43 pathology
  • Dorian McGavern, NINDS, NIH, USA, Immunological defense of dynamic vascular barriers in the meninges
  • Christoph Thaiss, Arc Inst.; Stanford Univ., USA, Environment-body-brain interactions

Monday, May 5 | 7:00 – 10:30 | Ballroom C

Major Symposium D

Chairs:

Memory and Effector B Cells in Health and Disease
  • F. Eun-Hyung Lee, Emory Univ. Sch. of Med., USA
  • Eric Meffre, Stanford Univ., USA

Speakers:

  • F. Eun-Hyung Lee, Emory Univ. Sch. of Med., USA, Understanding the complexity of human plasma cells
  • David Allman, Univ. of Pennsylvania, USA, Co-regulation of plasma cell function and survival
  • Nicole Weidner, Univ. of Texas Med. Br., Galveston, USA, Antigen avidity drives the durability of the vaccine immune response
  • Michel Nussenzweig, HHMI, Rockefeller Univ., USA, Plasma cell proliferation and antibody affinity maturation
  • Elliot H. Akama-Garren, Harvard Med. Sch., USA, PD-L1 promotes T cell help to B cells
  • Julie Zikherman, UCSF, USA, Balancing tolerance and immunity at the BCR
  • Eric Meffre, Stanford Univ., USA, B cell tolerance 

Tuesday, May 6 | 7:00 – 10:30 | Ballroom B

Major Symposium E
Evolving Immunologic Concepts Linking Infection and Autoimmunity

Chairs:

  • Judith James, Oklahoma Med. Res. Fndn., USA
  • Wei Jiang, Med. Univ. of South Carolina, USA

Speakers:

  • Hisashi Arase, iFReC, Osaka Univ., JPN, Self and neoself discrimination by T cells in the pathogenesis of autoimmune diseases
  • James J. Moon, Massachusetts Gen. Hosp.; Harvard Med. Sch., USA, T cell epitope spreading from microbial to autoantigens
  • Nada Abdel Aziz, Boston Children’s Hosp., USA, B cell isoform usage alterations in systemic lupus erythematosus
  • Wei Jiang, Med. Univ. of South Carolina, USA, Staphylococcus aureus peptidoglycan (PGN) induces pathogenic autoantibody production via autoreactive B cell receptor clonal selection, implications in systemic lupus erythematosus
  • Anam Shaikh, Univ. of Kansas, USA, PEP-R619W distinctly modulates persistent type-I interferon signaling to enhance DC and CD8+ T cell function
  • Judith James, Oklahoma Med. Res. Fndn., USA, Functional and molecular mimics link Epstein-Barr virus and lupus autoimmunity 
  • Martin Kriegel, Univ. of Münster, DEU, Gut commensal translocation in extraintestinal autoimmunity

Tuesday, May 6 | 7:00 – 10:30 | Ballroom C

Major Symposium F
Innate Immunity: Initiation and Regulation

Chairs:

  • Diana C. Hargreaves, Salk Inst. for Bio. Sts.
  • Dan Stetson, Univ. of Washington, USA

Speakers:

  • Lingyin Li, Arc Inst.; Stanford Univ., USA, The immunotransmitter cGAMP in cancer and autoimmunity
  • Grace E. Crossland, Dartmouth Col., USA, Mucosal-associated invariant T (MAIT) cells mediate IFN-I dependent immunosuppression in UV light-exposed skin: Implications for lupus photosensitivity
  • Pingwei Li, Texas A&M Univ., USA, The molecular basis of DNA sensing through the cGAS-STING pathway
  • Yung-An Huang, UCSD, USA, IL-18 receptor signaling regulates IL-17A expression in lung innate lymphoid cells during fungal allergen exposure
  • Kensuke Miyake, Chiba Univ., JPN, Toll-like receptor responses to lysosomal nucleic acid stress
  • Dan Stetson, Univ. of Washington, USA, The cGAS-STING pathway as a therapeutic target
  • Diana C. Hargreaves, Salk Inst. for Bio. Sts., USA, BAF complexes and tumor immunity

Wednesday, May 7 | 7:00 – 10:30 | Ballroom B

Major Symposium G
Lymphatic Immunophysiology

Chairs:

  • Gwendalyn J. Randolph, Washington Univ. Sch. of Med., St. Louis, USA
  • Melody Swartz, Univ. of Chicago, USA

Speakers:

  • Sandro Da Mesquita, Mayo Clin., Florida, USA, Modulation of brain physiology and pathology by the meningeal lymphatic system
  • Gwendalyn J. Randolph, Washington Univ. Sch. of Med., St. Louis, USA, Intestinal lymphatics and lymphoid tissue in gut immunophysiology
  • Ira Fleming, Univ. of Colorado Anschutz Med. Campus, USA, Stromal cells are targets for delivery of vaccine mRNA and can be leveraged for stable retention of foreign nucleic acid
  • Susan R. Schwab, New York Univ. Grossman Sch. of Med., USA, Far from home: T cell migration through non-lymphoid tissues
  • Changwei Peng, Harvard Med. Sch., USA, Endothelial CD130 controls the phenotype and function of high endothelial venules
  • Eric Hoyeon Song, Yale Univ., USA, Targeted lymphatic stimulation without angiogenic toxicities 
  • Melody Swartz, Univ. of Chicago, USA, Lymphatic clotting and its effects on adaptive immune responses

Wednesday, May 7 | 7:00 – 10:30 | Ballroom C

Major Symposium H
T Cell Differentiation in Cancer

Chairs:

  • Ana C. Anderson, Gene Lay Inst. of Immunol. and Inflammation, Brigham & Women’s Hosp., Harvard Med. Sch., USA
  • Mary Philip, Vanderbilt Univ. Sch. of Med., USA

Speakers:

  • Ben Youngblood, St. Jude Children’s Res. Med. Hosp., USA, Reverse translation of patient-identified epigenetic regulators limiting durable tumor immunotherapy
  • Mary Philip, Vanderbilt Univ. Sch. of Med., USA, Early CD8+ T cell fate commitment in cancer and infection
  • Katherine J. Horrigan, Univ. of Vermont, USA, Stk11-loss in lung adenocarcinoma is associated with an expansion of gd T cells with pro-tumor and immunosuppressive potential
  • Ana C. Anderson, Gene Lay Inst. of Immunol. and Inflammation, Brigham & Women’s Hosp.; Harvard Med. Sch., USA, Dynamic analyses reveal novel pathways that shape T cell differentiation during tumor progression
  • Zachary L. Hay, Oregon Hlth. & Sci. Univ., USA, Androgen receptor mediated suppression of CD4+ T cell anti-tumor immunity
  • Niroshana Anandasabapathy, Weill Cornell Med., USA, PD-1 and T cell specification